Prosthetic graft remnant-related pseudoaneurysm after left ventricular assist device explantation: a case report

Gregory N Messner 1, Chayanin Vatcharasiritham, Igor Gregoric, Branislav Radovancevic, Peggy Odegaard, Scott D Flamm, O H Frazier

Keywords: Pseudoaneurysm of the ascending aorta is a rare but severe complication of cardiac surgery. Most cases occur after coronary artery bypass grafting (CABG) and aortic valvular procedures, and many others occur after cardiac transplantation. Thus far, the only reported case of a pseudoaneurysm related to a left ventricular assist device (LVAD) is a pseudoaneurysm related to the prosthetic graft itself.

Clinical summary

In December 1999, a 47-year-old woman with a history of progressive dyspnea on exertion presented with a syncopal episode. She was admitted to a local hospital, where congestive heart failure was diagnosed. Echocardiography revealed an ejection fraction of 10%. The patient was transferred to St Luke’s Episcopal Hospital for further evaluation and treatment. There she underwent placement of an intra-aortic balloon pump, followed by simultaneous implantation of an LVAD (Thoratec VAD; Thoratec Corporation, Pleasanton, Calif) and performance of the Batista procedure. Three months later, in February 2000, the patient’s condition had improved to the point that the LVAD could be removed. Immediately after its removal, the patient experienced postoperative bleeding that required mediastinal exploration to control. The patient’s sternum was closed 1 day later. The patient did well for almost 1 year, until she complained of a painful swelling of the upper sternum. A computed tomography (CT) scan of the chest showed fluid anterior and posterior to the sternum extending back to the margin of the ascending thoracic aorta, a finding compatible with an abscess. The abscess was incised and drained after achievement of local anesthesia. A culture grown from a sample of the fluid grew methicillin-resistant Staphylococcus aureus. Intravenous vancomycin was instituted for 1 month. On follow-up examination, a repeat CT scan showed a 2.3-cm−diameter saccular aneurysm involving the distal ascending thoracic aorta and a parasternal collection of fluid containing air suggestive of an abscess. The abscess was surgically drained, and intravenous vancomycin was continued at a dosage of 0.5 g/d. Again, a culture grown from a sample of the drained fluid grew methicillin-resistant S aureus.
Magnetic resonance angiography (MRA) was performed to confirm the diagnosis of aneurysm of the ascending aorta. This revealed a pseudoaneurysm of the ascending aorta measuring 2.0 × 2.4 × 3.0 cm (Figure 1). Consequently, the patient was scheduled for resection of the pseudoaneurysm. The femoral vessels were exposed and readied for cannulation, and the sternum was opened with an oscillating saw. Because the pseudoaneurysm was adherent to the sternum, the opening of the sternum caused inadvertent entry into the pseudoaneurysm. The femoral vessels were immediately cannulated, and femorofemoral bypass was commenced. The patient was cooled to 18°C, and circulatory arrest combined with retrograde cerebral perfusion was initiated. Then the sternum was slowly opened. After reduction of the blood flow to 500 mL/min, the patient was placed in the Trendelenburg position to prevent air embolism. The pseudoaneurysm, together with the remnant of the prosthetic graft still attached to the ascending aorta, was resected. The pre-existing anastomosis between the prosthetic graft and the ascending aorta was found to be disrupted for about one third of its entire circumference. The disrupted portion of the anastomosis was resected, leaving a 3 × 2–cm defect at the aorta, and further dissection of the ascending aorta was done to facilitate crossclamping. After crossclamping, the patient was warmed to 32°C and then subjected to retrograde cerebral perfusion. The defect at the aorta was repaired by using an oval Dacron patch. The crossclamp was then released, and the patient was warmed to 37°C and weaned off cardiopulmonary bypass. The sternum was left open until the next day, when the patient was brought back to the surgical theater for placement of an omental graft and closure of the sternum. Even though cultures of the resected pseudoaneurysm specimen did not grow any organisms, an antibiotic therapy regimen was instituted. Postoperatively, the patient remained stable and was discharged home after 2 weeks.
 

Figure 1 Surface-shaded rendering of the thoracic aorta in the lateral projection superimposed on a single sagittal slice of the chest, as acquired by means of 3-dimensional MRA. The arrowheads denote the sternum and show the proximity of the pseudoaneurysm (arrow) when considering re-exploration. The twisting line between the pseudoaneurysm and the sternum indicates the right internal thoracic artery.

At 1 year of follow-up, the patient was stable with no neurologic deficits. A CT scan of the chest showed normal findings and confirmed that the Dacron patch repair was still intact (Figure 2). The antibiotic regimen was discontinued on the recommendation of an infectious disease consultant.

Figure 2 CT scan of the chest, taken at 1 year of follow-up, showing normal findings and confirming that the Dacron repair graft was still intact.

Discussion

This report documents the first case of a pseudoaneurysm related to the removal of an LVAD. CT scanning and MRA confirmed the diagnosis, and surgical intervention was performed to correct the problem.
Although cardiac transplantation is the therapeutic option of choice and currently the most frequent treatment for end-stage heart failure, wider use of this approach has been limited by several issues. These include fewer available donor hearts than transplant candidates and the resultant long waiting period for an organ. In addition, there are the usual problems of rejection faced by all transplant recipients and the heart-specific problem of coronary graft atherosclerosis, which can significantly limit the long-term survival of heart recipients.
 During the past 2 decades, temporary mechanical circulatory support has become a widely accepted option for patients with intractable heart failure, particularly those awaiting cardiac transplantation. An unexpected benefit of prolonged LVAD use has been improved ventricular function in patients with idiopathic and dilated cardiomyopathies. In a few cases in which LVAD removal was necessitated by device failure or device-related infection, the patient’s native cardiac function had recovered sufficiently to avoid subsequent transplantation or reimplantation of an assist device.
 Prolonged mechanical unloading of the failing heart by an LVAD promotes ventricular recovery (ie, improved cardiothoracic ratio, end-diastolic dimension, ejection fraction, pulmonary capillary wedge pressure, and pulmonary vascular resistance and also striking histologic improvement of the myocardium).
,  
 This unexpected benefit of prolonged LVAD use has led to another indication for LVAD support: bridging to recovery. Although this new use of an LVAD is promising, this case demonstrates that the device might also lead to unexpected complications, such as the development of a pseudoaneurysm.
Typically, pseudoaneurysm of the ascending aorta is thought to be an unusual and potentially fatal complication of cardiovascular surgery. Most pseudoaneurysms are associated with aortic valve or CABG surgery and are often infectious in origin. In several reported series, infected pseudoaneurysms occurred along the aortic suture lines after cardiac transplantation. However, to our knowledge, there has never been any report of a case of an infected pseudoaneurysm of the prosthetic graft remnant that remains attached to the ascending aorta after LVAD removal. The only similar report in the literature is of a pseudoaneurysm of the outflow graft itself in a patient supported with a Novacor N100 left ventricular assist system (Baxter Healthcare Corp, Oakland, Calif).
Because the ascending aorta has been the preferred site for arterial cannulation for primary heart operations for the past 2 decades, and because the number of CABG and aortic valvular procedures involving entry into the ascending aorta has increased, pseudoaneurysms of the thoracic aorta have become more frequent.
,  
 Predisposing factors include graft infection, dissected native aorta, and possibly tissue necrosis after excessive use of biologic glue.
 Pseudoaneurysms are the result of disruption of at least one layer of the vessel wall and are contained by the remaining vascular layers or the surrounding structures of the mediastinum with or without development of a neointima. In this respect, pseudoaneurysms differ from true aneurysms, in which all 3 vascular layers remain intact.
 Although this pseudoaneurysm was the result of an infection and breakdown of the anastomotic graft stump, we were able to repair the defect with a prosthetic patch, with no untoward effects.
As the present case makes clear, follow-up is essential for LVAD-supported patients who undergo device removal and are left with a remnant of the prosthetic graft attached to the ascending aorta because the remnant has the potential to become a focus of infection or to develop into a pseudoaneurysm. In cases of mediastinal infection in this subgroup of patients, early MRA should be done because it might easily reveal the presence of a pseudoaneurysm. Surgical management is essential in the setting of pseudoaneurysms after LVAD explantation.

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Article Info

Publication History

Accepted: December 16, 2002
Received: November 13, 2002

Identification

DOI: https://doi.org/10.1016/S0022-5223(03)00129-6

Copyright

© 2003 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

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Learn about prosthetic graft remnant-related pseudoaneurysm, a rare vascular complication where a false aneurysm forms at the site of a previous graft, requiring timely diagnosis and intervention.

Párrafo de 300 palabras:
A prosthetic graft remnant-related pseudoaneurysm is a rare but serious complication that can occur after vascular surgery where a prosthetic graft has been used to repair damaged blood vessels. This condition involves the formation of a false aneurysm at the site where the graft material meets the native blood vessel, due to incomplete healing or weakening of the vessel wall. The pseudoaneurysm is not a true aneurysm, as it does not involve all layers of the blood vessel wall but is instead a collection of blood outside the vessel, contained only by the surrounding tissue.

The development of a prosthetic graft remnant-related pseudoaneurysm can occur months or even years after the initial surgery. Common symptoms may include localized swelling, pain, or pulsation at the graft site, though in some cases, the condition may be asymptomatic and discovered incidentally during imaging studies. If left untreated, the pseudoaneurysm can rupture, leading to life-threatening hemorrhage.

The diagnosis of prosthetic graft remnant-related pseudoaneurysm typically involves imaging techniques such as ultrasound, CT scan, or MRI, which can visualize the abnormal blood collection and assess the size and risk of rupture. Early detection is crucial for preventing severe complications.

Treatment options for prosthetic graft remnant-related pseudoaneurysm depend on the size, location, and risk of rupture. In some cases, observation and monitoring are sufficient, especially for smaller or asymptomatic pseudoaneurysms. However, larger or symptomatic pseudoaneurysms often require surgical intervention, such as repair of the graft or embolization, to prevent rupture and restore normal blood flow.

Overall, a prosthetic graft remnant-related pseudoaneurysm is a serious vascular complication that requires prompt diagnosis and treatment to prevent severe consequences. Regular follow-up and imaging are essential for patients who have undergone vascular surgeries involving prosthetic grafts.

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